Professor of Biological Sciences
Robert & Jane Meyerhoff Chair of Biochemistry
University of Maryland, Baltimore County (UMBC)
Dr. Ostrand-Rosenberg joined the University of Maryland Baltimore County (UMBC) faculty in 1977 after completing her Ph.D. at The California Institute of and post-doctoral work at The Johns Hopkins University. She is Professor of Biological Sciences and the Robert & Jane Meyerhoff Professor of Biochemistry and a member of the Greenebaum Cancer Center at the University of Maryland, Baltimore. Her research program focuses on understanding the role of the immune system in cancer, with the goal of manipulating the immune response to reject metastatic cancer cells. In the 1990’s her laboratory was instrumental in demonstrating that CD4+ T helper lymphocytes contribute to tumor rejection. Within the past ~12 years her lab has focused on tumor-induced immune suppression, and has made seminal contributions to identifying myeloid-derived suppressor cells (MDSC) as immune suppressive cells in individuals with cancer. These studies provided insight into the causative relationship between inflammation and cancer by demonstrating that chronic inflammation induces MDSC. Her lab is currently developing strategies to neutralize immune suppression and promote antitumor immunity. Her research is reported in over 125 publications.
Dr. Ostrand-Rosenberg is the recipient of numerous awards, including an American Cancer Society Faculty Research Award, University of Maryland System Award for Excellence in Research, UMBC Presidential Research Professor Award, Johns Hopkins Society of Fellows, and the American Association of Immunologists Excellence in Mentoring Award. She has over 25 years of service on national and international grant panels and advisory committees, including the National Institutes of Health National Cancer Institute Board of Scientific Counselors, State of Maryland Stem Cell Commission, and senior editor for the journal Cancer Research. She is currently editor-in-chief for Cancer Immunology, Immunotherapy and deputy editor for the Journal of Immunology. Her laboratory has been financially supported since 1978 by grants from multiple federal agencies including the NIH, DOD, and NSF, as well as by private research foundations and industry.